Table 1. Patients and Sample Characteristics.
| Sample | Tissue | Ethnicity | HIV Status | KSHV Copy per 106 Cells in biopsy tissue | K1 | MicroRNA Cluster | K12/T0.7 |
|---|---|---|---|---|---|---|---|
| UW1 | control | African | pos | 545 | A5 | partial | A5 |
| HAMB1 | control | African American | pos | QP | C1 | partial | ND |
| HAMB2 | control | Hispanic | pos | undetectable | ND | partial | ND |
| HAMB3 | control | African American | neg | 850 | A1 | A/C | C |
| UW2 | KS | African | pos | 16,364,000 | B1 | A5/B/F | B |
| UW3 | KS | African | pos | 230,000 | A5 | A5/B/F | A5 |
| UW4 | KS | African | pos | 307,000 | A5 | A5/B/F | A5 |
| UW5 | KS | African | pos | 76,000 | ND | A5/B/F | A5 |
| UW6 | KS | African | pos | 109,000 | B1 | A5/B/F | A5 |
| HAMB4 | KS | African American | pos | 6,100 | A4 | A/C | A |
| HAMB5 | KS | Caucasian | neg | 533,000 | A1 | A/C | A |
| HAMB6 | KS | African American | pos | 8,500,000 | A2 | A/C | A |
| HAMB7 | KS | Caucasian | pos | 744,000 | C3 | A/C | C |
| HAMB8 | KS | Caucasian | neg | 248,000 | C1 | A/C | C |
| HAMB9 | KS | Caucasian | pos | 19,000 | A2 | A/C | A |
| HAMB10 | KS | Caucasian | pos | 40,000 | A4 | A/C | A |
| HAMB11 | KS | African American | pos | 341,500 | A4 | A/C | C |
| HAMB12 | KS | Hispanic | pos | 12,429,000 | C3 | A/C | C |
| HAMB13 | KS | Caucasian | neg | 584,000 | A4 | A/C | C |
| HAMB14 | KS | Caucasian | neg | 683,500 | A4 | A/C | C |
| HAMB15 | KS | Caucasian | neg | 121,000 | A4 | A/C | C |
| HAMB16 | KS | Hispanic | pos | 515,000 | A4 | A/C | C |
| HAMB17 | KS | African American | pos | 17,000 | C3 | A/C | C |
| HAMB18 | KS | Caucasian | pos | 1,907,000 | C3 | A/C | C |
The characteristics of all patients including ethnicity, HIV status, and estimated KSHV viral load in biopsy tissues are as indicated. The viral K1, microRNA cluster, and K12/T0.7 subtypes are indicated as A-F depending on phylogenetic analysis classification (referencing Figures 1A-1C). KSHV copies per million cells rounded to three significant figures. Partial microRNA sequences were obtained for UW1, HAMB1, and HAMB2 but subtype was not determined due to insufficient overlap of sequence reads. K1 sequence was not successfully determined for HAMB2 and UW5.
Abbreviations: ND=not determined. UW=samples from University of Witwatersrand, South Africa. HAMB=samples from HIV and AIDS Malignancy Branch, NCI-Bethesda, Maryland. KS=Kaposi's sarcoma. Pos=positive; Neg=negative; QP=qualitative positive sample with average estimated copy number less than 3.