Table 1.
Commercially available macromolecular drugs applied via nasal route.
| Drugs | Molecular weight (Da) | Formulation | Commercial name | Company | FDA approval date |
|---|---|---|---|---|---|
| Desmopressin acetate | 1183 | Solution, Spray | Minirin® | Sanofi-Aventis | 1978 |
| Salmon calcitonin | 3432 | Solution, Spray | Miacalcin® | Novartis | 1995 |
| Buserelin acetate* | 1239 | Solution, Spray | Suprefact® | Sanofi-Aventis | - |
| Nafarelin acetate | 1321 | Solution, Spray | Synarel® | Pfizer | 1990 |
| Oxytocin | 1007 | Solution, Spray | Syntocinon® | Novartis | 1995 |
| Cyanocobalamine | 1355 | Gel | Nascobal® | Par Pharm Co. | 1996 |
| Cyanocobalamine | 1355 | Solution, Spray | Nascobal® | Par Pharm Co. | 2005 |
* Approved in Canada.