Table 2.

Cytotoxic activities of compounds 1–26 against the PC-3 cell line.

Compound	R	PC-3 cell line
		IC50 (μM)
1	phenyl	6.8
2	4-cyanophenyl	10.0
3	4-(trifluoromethyl)phenyl	NEa
4	4-chlorophenyl	NE
5	4-methylphenyl	NE
6	4-tert-butylphenyl	NE
7	4-methoxyphenyl	NE
8	2-chlorophenyl	NE
9	2-bromophenyl	NE
10	2-iodophenyl	NE
11	benzyl	2.9
12	2-phenylethyl	NE
13	3,5-dichlorophenyl	NE
14	3,5-dimethoxyphenyl	4.0
15	3,4,5-trimethoxyphenyl	NE
16	3,4-methylenedioxyphenyl	NE
17	naphthyl	NE
18	diphenylmethyl	NE
19	4-pyridyl	NE
20	3-pyridyl	NE
21	3-(2-chloropyridyl)	10.0
22	3-(2-propylthiopyridyl)	NE
23	2-thienyl	NE
24	pyrazinyl	NE
25	2-quinolyl	NE
26	3-quinolyl	NE
MSAb		8.38 [33]
Etoposide		13.6 ± 2.2 [34]

^a NE = no effect is observed; ^b methylseleninic acid.