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. 2018 Nov 26;138(22):2499–2512. doi: 10.1161/CIRCULATIONAHA.118.034942

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© 2018 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 2. — Consistency of metabolic effects of statin treatment and PCSK9 rs11591147-T. The effect size of each metabolic measure is given with 95% confidence intervals in gray vertical and horizontal error bars. Color coding for the metabolic measure indicates the P value for heterogeneity between statin therapy and PCSK9 rs11591147-T. R² = 0.880 indicates goodness of fit (correlation squared). The red dashed line denotes the linear fit for the consistency of the metabolic effects (slope of this line = 0.879). C indicates cholesterol; FA, fatty acids; FC, free cholesterol; HDL, high-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; PL, phospholipids; PUFA, polyunsaturated fatty acids; TG, triglycerides; and VLDL, very-low-density lipoprotein. A full list of metabolite names is given in Table II in the online-only Data Supplement.