Table 2.
IC50 values related to PET inhibition in spinach chloroplasts in comparison with 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) standard and in vitro antimycobacterial activity MIC/IC90 of compounds 1-3i, 4a-4e in comparison with the standard, isoniazid (INH).
| Comp. | PET inhibition IC50 [μmol/L] | MIC/IC90 [µg/mL] | |||
|---|---|---|---|---|---|
| M. smegmatis | M. absessus | M. kansasii | M. avium complex | ||
| 1 | a | >300 | >300 | >300 | >300 |
| 2 | 362 | >300 | >300 | >300 | >300 |
| 3a | a | >300 | >300 | >300 | >300 |
| 3b | a | >100 | >100 | >100 | >100 |
| 3c | a | >100 | >100 | >100 | >100 |
| 3d | 693 | >100 | >100 | >100 | >100 |
| 3e | 391 | >100 | 80 | 20 | 80 |
| 3f | 1034 | >300 | >300 | >300 | >300 |
| 3g | a | >100 | >100 | >100 | >100 |
| 3h | 561 | >100 | >100 | >100 | >100 |
| 3i | 665 | >100 | >100 | >100 | >100 |
| 4a | 285 | >100 | >100 | >100 | >100 |
| 4b | a | >100 | 80 | 60 | 80 |
| 4c | 303 | >100 | >100 | 60 | >100 |
| 4d | 390 | >100 | >100 | >100 | >100 |
| 4e | 508 | >100 | >100 | >100 | >100 |
| DCMU | 1.9 | – | – | – | – |
| INH | – | 39 | >100 | <10 | <10 |
a precipitation during the experiment or interaction with DCPIP.