Table 1.
The substituents of target compounds and their antiproliferative effects in K562 cells.
| Compound | R | GI50 (μM) in K562a |
|---|---|---|
| 12a | H | 2.01 ± 0.10 |
| 12b | 2-F | 0.67 ± 0.07 |
| 12c | 2-Cl | 0.10 ± 0.01 |
| 12d | 2-Br | 0.07 ± 0.01 |
| 12e | 2-NO2 | 0.26 ± 0.02 |
| 12f | 2-OCH3 | 0.83 ± 0.05 |
| 12g | 2-OCH2CH3 | 1.55 ± 0.21 |
| 12h | 4-F | 1.83 ± 0.09 |
| 12i | 4-Cl | 1.26 ± 0.04 |
| 12j | 4-Br | 0.55 ± 0.05 |
| 12k | 4-NO2 | 0.39 ± 0.04 |
| 12l | 4-CH3 | 0.51 ± 0.02 |
| 12m | 4-OCH3 | 1.05 ± 0.06 |
| 12n | 4-OCH2Ph | > 5 |
| 12o | 2,3-di-OCH3 | 0.14 ± 0.01 |
| 12p | 2,4-di-OCH3 | 1.26 ± 0.05 |
| 12q | 2,3,4-tri-OCH3 | 0.78 ± 0.06 |
| 12r | 3,4-di-OCH3 | 0.99 ± 0.17 |
| 12s | 3-OCH3,4-OCH2CH3 | > 5 |
| 12t | 3-OCH2CH3,4-OCH3 | 0.48 ± 0.04 |
| 12u | 3-OCH3,4-OCH2Ph | > 5 |
| 12v | 3-OCH2Ph,4-OCH3 | > 5 |
| 12w | 3,4(-OCH2O-) | 0.57 ± 0.02 |
| 15 | 3.51 ± 0.33 | |
| STI-571 | 0.23 ± 0.01 |
a GI50 is the concentration that inhibits 50% of cell growth. Cells were seeded at 4.0 × 104 cells/mL and incubated with various concentrations of tested compounds for 72 h. The data shown are the mean ± SE of three independent experiments.