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. 2018 Nov 20;10:5951–5964. doi: 10.2147/CMAR.S185270

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© 2018 Xiao et al. This work is published and licensed by Dove Medical Press Limited

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TRIM2 is downregulated in ccRCC cells and tissues.

Notes: (A and B) Gene expression levels of TRIM2 in renal cancer cell lines. (C and D) qRT-PCR and IHC analyses of TRIM2 expression in ccRCC tissues and paracancer tissues. (E) Gene set enrichment analysis compared low TRIM2 and high TRIM2 expression groups in TCGA database. Enrichment curves are shown for activated gene sets related to G2M checkpoint, EMT, hypoxia pathway, and Myc signaling.

Abbreviations: ccRCC, clear cell renal cell carcinoma; EMT, epithelial–mesenchymal transition; FDR, false discovery rate; IHC, immunohistochemistry; TCGA, The Cancer Genome Atlas; TRIM2, tripartite motif 2; NES,normalized enrichment score.