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. 2018 Oct 31;54(1):7–16. doi: 10.3892/ijo.2018.4612

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Copyright: © Yan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The expression of IL-21R is upregulated in gastric cancer (GC) samples. (A) Immunohistochemical (IHC) analysis of the protein expression of IL-21R in gastric adenocarcinoma (GAC) samples and adjacent normal samples (n=89; magnification, ×400). (B) TCGA cohort analysis of the mRNA expression level of IL-21R in unpaired and paired GAC samples. (C) RT-qPCR and western blot analysis of the expression level of IL-21R in GC cell lines and GES-1 normal cells. (D) The genetic and copy number alterations of IL-21R in GC. Proportion of genetic alterations of IL-21R, and the association between IL-21R expression level and its putative copy number alterations are shown. (E) Kaplan-Meier analysis of the association of IL-21R expression with poor survival and recurrence in patients with GC. (F) TCGA cohort analysis of the association of IL-21R expression with overall survival and recurrence in patients with GC.