Table I.
Prediction of miRNA candidates by in silico gene ontology analysis.
| miRNA | Confidence | Gene | Key pathways |
|---|---|---|---|
| 132-3p | High | SMAD2 | TGFβ, EMT |
| 132-3p | High | SMAD5 | TGFβ, EMT |
| 132-3p | High | GSK3β | TGFβ, Wnt, EMT |
| 132-3pa | Moderatea | TGF-β2a | TGFβ, EMTa |
| 132-3p | High | KRAS | PDA, EMT |
| 132-3p | High | MAPK1 | MAPK, EMT |
| 132-3p | High | FOXO3 | GCs |
| 1275 | Moderate | SMAD3 | SMAD, EMT |
| 1275 | Moderate | SMAD9 | SMAD, EMT |
| 210 | High | INHBB | TGFβ, EMT |
| 210 | High | ACVR1B | Wnt, EMT |
| 210 | Moderate | SOX15 | Wnt, EMT |
| 1246 | High | GSK3β | TGFβ, Wnt, EMT |
| 1246 | High | CDH2 | Cell-cell junctions |
| 1246 | High | AXIN2 | Wnt, EMT |
| 1260b | High | Bcl2 | Apoptosis |
| 1260b | High | Akt2 | MAPK, PI3K |
| 378i | High | BMP2 | TGFβ, EMT |
| 378i | High | MAPK1/9 | MAPKs |
| 99a-5p | High | BMPR2 | Wnt, TGFβ |
a
Top candidate. The keywords ‘glucocorticoids’, ‘epithelial-mesen-chymal-transition’, ‘apoptosis’, ‘Wnt’ and ‘Smad’ were used for in silico prediction analysis. A confidence of ‘high’ or ‘moderate’ was assigned based on the level of evidence provided by miRNAseq experiments, as described by the online database miRBase.