Fig. 1.

Histology and differentiation markers of representative raft cultures. HPV-18 (A) infected and (B) uninfected day 13 PHK raft cultures were exposed, from days 6 to 13, to DMSO and 1 or 5 μM Vorinostat. Four-micrometer sections of FFPE tissues were stained with hematoxylin and eosin (Upper). Indirect IF detection of loricrin (red) and keratin 10 (green) (Lower). Brackets denote stratum granulosum. Microphotographic images here and in later figures were captured with a 20× objective, and DAPI staining (blue) revealed all nuclei.