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Prolonged exposure of HPV-18−infected raft culture to Vorinostat. The day 22 cultures were exposed to DMSO or 1 or 5 μM Vorinostat from days 6 to 22. Histology was revealed by staining with hematoxylin and eosin (Upper). DNA damage and apoptosis were detected by indirect immunofluorescent detection of γ-H2AX and TUNEL (Lower).
