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. 2009 Dec 9;14(12):5124–5143. doi: 10.3390/molecules14125124

Table 2.

Synthesis of 1,4-disubstituted-1,2,3-triazoles.

graphic file with name molecules-14-05124-i002.jpg

Compound R1 R2 R3 R4 Yield (%)
20 H CH2Ph CH2Ph - 87
21 CH2Ph H CH2Ph - 91
22 H CH2CH2Ph CH2Ph - 92
23 H CH2OCH2Ph Si(CH3)2C(CH3)3 - 67
24 H CH2Ph H CO2CH3 71
25 H CH(CH3)2 H CO2CH3 74
26 H CH2Ph H Ph 97
27 H CH2Ph CH2Ph CO2CH3 83
28 CH2Ph H CH2Ph CO2CH3 90
29 H CH2CH2Ph CH2Ph CO2CH3 82

(i) BnCl, NaH, TBAI, THF, 15 h, RT; or TBDMSiCl, imidazole, DMF, 15 h, RT; (ii) sodium ascorbate, CuSO4 in H2O:t-BuOH (1:1 v/v), 15h, RT.