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. 2009 Jul 10;14(7):2491–2500. doi: 10.3390/molecules14072491

Table 1.

Evaluation of synthetic lactones activity against Leishmania panamensis.

Compound Cytotoxicity Leishmanicidal Activity
LC50 (μg/mL) EC50 (μg/mL) SI*
6 27.6 ± 5.9 37.9 ± 1.4 0.7
7 54.1 ± 3.1 22.2 ± 3.2 2.4
8 3.5 ± 0.4 0.8 ± 0.2 4.4
9 33.9 ± 1.4 2.8 ± 0.8 12.1
10 1.4 ± 0.1 4.5 ± 0.3 0.3
11 0.4 ± 0.03 1.6 ± 0.2 0.3
12 1.0 ± 0.04 8.6 ± 0.3 0.1
13 2.5 ± 0.3 7.5 ± 2.1 0.3
14 2.2 ± 0.3 1.9 ± 0.1 1.2
15 1.0 ± 0.01 1.4 ± 0.3 0.7
16 51.2 ± 6.0 47.2 ±10.3 1.1
graphic file with name molecules-14-02491-i001.jpg
3.7** 0.20** 18.5**
graphic file with name molecules-14-02491-i002.jpg
4.0** 0.22** 18.1**
graphic file with name molecules-14-02491-i003.jpg
45.1** 3.42** 13.2**
Glucantime 416.4 6.7 59.6

*SI=LC50/EC50; ** biological results reported in the literature [10].