Table 1.
Antimycobacterial activity (MIC, IC90 and IC50 values) of the tested compounds 1-12 in comparison with standard (PZA).
| Compd. | Regional Hospital in Pardubice (Czech Republic) | TAACF (USA) | ||||
|---|---|---|---|---|---|---|
| MIC [mg/L-1] | M. tuberculosis H37Rv | |||||
| M. tuberculosis H37Rv | M. kansasii CNCTC My 235/80 | M. avium CNCTC My 66/72 | M. avium 152/74 | IC50 [μg/mL] | IC90 [μg/mL] | |
| 1 | 2 | 128 | >128 | >128 | >100 | >100 |
| 2 | 8 | 32 | >128 | >128 | >100 | >100 |
| 3 | 8 | >128 | >128 | >128 | >100 | >100 |
| 4 | 8 | >128 | >128 | >128 | >100 | 20.703 |
| 5 | 2 | >128 | >128 | >128 | >100 | >100 |
| 6 | >128 | >128 | >128 | >128 | >100 | >100 |
| 7 | 32 | >128 | >128 | >128 | >100 | >100 |
| 8 | 16 | >128 | >128 | >128 | >100 | >100 |
| 9 | <2 | >128 | >128 | >128 | >100 | 69.099 |
| 10 | 8 | >128 | >128 | >128 | >100 | >100 |
| 11 | 8 | >128 | >128 | >128 | >100 | >100 |
| 12 | 4 | >128 | >128 | >128 | 0.728 | 0.819 |
| PZA | 8 | >128 | >128 | >128 | -a | >20b |
a not obtained; b from reference, test date 05/30/2007 [17].