Author response image 1. Mechanical sensitivity after injection of complete Freund`s adjuvant.

Line chart displays mechanical withdrawal thresholds from old (≥12 months) wildtype (WT) and α-galactosidase A deficient (GLA KO) mice, calculated as percent change from baseline. Old WT mice were slightly more sensitive to mechanical stimulus, which was not significant except for 48 hours after CFA injection compared to old GLA KO mice. Data were analyzed using two-way ANOVA following Tukey’s post-hoc test after data transformation using Johnson’s procedure.