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. 2009 Dec 7;14(12):5042–5053. doi: 10.3390/molecules14125042

Table 1.

The structures of 5a, 5b, 8-12 and their cytotoxicities against H460 cell line.

graphic file with name molecules-14-05042-i001.jpg

Compound R1 R2 IC50a (μM)
5a H graphic file with name molecules-14-05042-i002.jpg 11.6
5b OMe graphic file with name molecules-14-05042-i003.jpg 53.8
8 H graphic file with name molecules-14-05042-i004.jpg 68.1
9 H graphic file with name molecules-14-05042-i005.jpg 6.1
10 H graphic file with name molecules-14-05042-i006.jpg 46.8
11 H graphic file with name molecules-14-05042-i007.jpg 53.4
12 H graphic file with name molecules-14-05042-i008.jpg 62.9

Adriamycin used as positive control, IC50 = 1.72 μM.