Table 1.
Analyses of genome profiles generated by OEhMSCs cultured in the RWV on beads coated with OEhMSC-derived ECM as compared to collagen I
| A | ||
|---|---|---|
| Gene ontology | ||
| Term | P-value | Enrichment |
| Response to mechanical stimulus | 1.90E−06 | 7.4 |
| Integrin binding | 2.90E−04 | 4.2 |
| Cellular response to hypoxia | 7.00E−04 | 4.1 |
| Positive regulation of cell migration | 2.40E−04 | 3.2 |
| Positive regulation of gene expression | 1.10E−05 | 3.2 |
| ECM organization | 4.60E−04 | 3 |
| Proteinaceous ECM | 3.80E−05 | 3 |
| Aging | 3.10E−03 | 2.9 |
| Cell–cell adhesion | 1.90E−04 | 2.8 |
| Cadherin binding involved in cell–cell adhesion | 1.30E−04 | 2.8 |
| Heparin binding | 6.90E−03 | 2.8 |
| ECM | 1.40E−04 | 2.7 |
| Mitochondrial outer membrane | 1.10E−02 | 2.7 |
| Angiogenesis | 1.60E−03 | 2.7 |
| Focal adhesion | 4.10E−05 | 2.6 |
| B | ||
| Tissue expression | ||
| Term | P -value | Enrichment |
| Bonea | 1.40E−08 | 4 |
| Bone marrowb | 8.40E−11 | 3.9 |
| Ovary | 3.30E−10 | 3.7 |
| Eye | 2.10E−08 | 3.7 |
| Brain | 1.80E−09 | 3.7 |
| Lung | 9.40E−08 | 3.4 |
| Eye | 4.70E−10 | 3.3 |
| Vascular | 1.90E−05 | 2.5 |
| Thyroid | 2.10E−04 | 2.3 |
a,b refer to Table S2 and 3, respectively
A list of those transcripts with 2-fold greater transcription when hMSCs differentiated to OEhMSCs on ECM as compared to on collagen I was subjected to analysis using the DAVID database. A: Gene ontology clustering. B: Association with known tissue expression signatures. The definition of P-values and Enrichment Scores are provided in Huang da et al.31,32