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. 2018 Nov 26;8:17361. doi: 10.1038/s41598-018-35407-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The KIRA reveals dose dependent differences in the abilities of IGF-TRAPs 3.1 and 3.3 to reduce the bioavailability of circulating IGF-1. Blood was collected daily from mice that underwent injections with IGF-TRAP 3.1 (A) or IGF-TRAP 3.3 (B) at doses of 0.5 mg/kg or 10 mg/kg on alternate days (as indicated by arrows). Shown in (A,B) are plasma levels of bioavailable IGF-1, as measured by the KIRA for the indicated time intervals, and in (C) are the concentration/time ratios calculated based on the data. *p < 0.05, **p < 0.01, ***p < 0.001.