Table 1.
Clinical metabolic and corneal endothelial and nerve parameters in control subjects and patients with acute ischemic stroke.
| Variables | Controls | Stroke | P value |
|---|---|---|---|
| Number of Participants | 18 | 146 | |
| Age (years) | 47.73 ± 3.10 | 48.93 ± 0.79 | 0.714 |
| Gender (M/F) | (11/7) | (141/5) | <0.001 |
| BMI (kg/m2) | 25.78 ± 0.63 | 29.40 ± 0.83 | 0.217 |
| NIHSS Score | N/A | 4.08 ± 0.33 | NA |
| Triglycerides (mmol/l) | 1.23 ± 0.24 | 1.86 ± 0.10 | 0.053 |
| Total Cholesterol (mmol/l) | 4.63 ± 0.35 | 5.05 ± 0.10 | 0.337 |
| LDL (mmol/l) | 2.96 ± 0.33 | 3.27 ± 0.09 | 0.421 |
| HDL (mmol/l) | 1.10 ± 0.07 | 0.94 ± 0.02 | 0.058 |
| BP Systolic (mmHg) | 120.40 ± 3.96 | 161.03 ± 2.47 | <0.001 |
| BP Diastolic (mmHg) | 73.60 ± 2.44 | 94.10 ± 1.41 | <0.001 |
| HbA1c (%) | 5.36 ± 0.17 | 6.83 ± 0.18 | 0.035 |
| Diabetes Duration (years) | NA | 7.94 ± 7.50 | NA |
| Mean ECD (no./mm2) | 3664.72 ± 43.88 | 3342.87 ± 27.45 | <0.001 |
| Mean ECA (µm2) | 219.81 ± 2.69 | 244.37 ± 2.05 | <0.001 |
| Mean ECP (µm) | 52.95 ± 0.35 | 55.74 ± 0.25 | <0.001 |
| Polymegathism (%) | 52.26 ± 1.31 | 52.39 ± 0.44 | 0.923 |
| Pleomorphism (%) | 33.51 ± 1.21 | 33.60 ± 0.50 | 0.953 |
| CNFD (no./mm2) | 37.54 ± 1.97 | 28.73 ± 0.65 | <0.001 |
| CNBD (no./mm2) | 73.96 ± 6.15 | 49.35 ± 2.26 | < 0.001 |
| CNFL (mm/mm2) | 21.31 ± 1.01 | 16.92 ± 0.42 | 0.001 |
BMI (Body Mass Index), NIH stroke severity (NIHSS), LDL (Low Density Lipoprotein), HDL (High Density Lipoprotein), BP (Blood Pressure), HbA1c (Glycated hemoglobin), mean ECD (Endothelial Cell Density), mean ECA (Endothelial Cell Area), mean ECP (Endothelial Cell Perimeter), CNFD (Corneal nerve fibre density), CNBD (Corneal nerve branch density), CNFL (Corneal nerve fibre length). Results are expressed as mean ± SE with significance indicated by the exact P value.