Table 1.

Demographics, clinical characteristics and hippocampal volumes by cognitive diagnosis.

Total n = 183	Cognitively healthy (n = 112)	CIND (n = 26)	Dementia (n = 45)	p-value
Sex male (%)	43 (38.4)	10 (38.5)	22 (48.9)	0.463
Age (years)‡§	78.0 [76.0, 81.2]	80.0 [78.2, 83.7]	77.0 [72.0, 82.0]	0.004
Education (years) †‡§	4.0 [3.0, 8.2]	2.0 [0.0, 4.0]	8.0 [3.0, 14.0]	<0.001
MMSE†‡	26.5 [24.0, 28.0]	21.0 [17.0, 24.5]	24.0 [20.0, 26.0]	<0.001
BCB learning†‡§	23.0 [20.0, 25.0]	17.5 [15.0, 21.5]	17.0 [15.0, 20.0]	<0.001
BCB delayed recall†‡§	8.0 [7.0, 9.0]	6.0 [5.0, 7.0]	4.0 [3.0, 5.0]	<0.001
Right hippocampus†‡	1.6 (0.1)	1.5 (0.2)	1.4 (0.2)	<0.001
Left hippocampus†‡	1.5 (0.1)	1.4 (0.2)	1.3 (0.1)	<0.001
Volume of white matter lesions	5029.9 [1297.1, 11885.8]	6165.3 [2447.7, 20117.6]	1671.8 [277.9, 5489.1]	<0.001

Age, education, the Mini-Mental State Examination (MMSE), the Brief Cognitive Battery (BCB) learning, delayed recall scores and the volume of white matter lesions are depicted in median [Interquartile intervals] and the between-group differences were calculated using Kruskal-Wallis. The left and right hippocampal volumes are depicted in mean (standard deviation) and the between-group differences were calculated using one-way ANOVA. The hippocampi volumes are corrected for the total intracranial volume and are shown in cm³. CIND, Cognitive impairment-no dementia. ^†Cognitively healthy compared with CIND, ^‡Cognitively healthy compared with Dementia, ^x CIND compared with dementia.