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. 2018 Nov 20;12:437. doi: 10.3389/fncel.2018.00437

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Copyright © 2018 Tan, Wen, Li, Wang, Qian, Pan, Lai, Deng, Hu, Zhang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CT04 suppresses SC proliferation. (A–G) EdU staining showed that EdU positive ratio was suppressed by CT04 treatment (n = 15, *P < 0.05). (H) Statistical graph of cell density indicated that the number of total cells (positive for 4′,6-diamidino-2-phenylindole (DAPI)) was decreased in the presence of CT04 (n = 15, *P < 0.05). (I) Water-soluble tetrazolium salt-1 (WST-1) measurement revealed that CT04 markedly decreased the absorbance value compared to the control group (n = 4, *P < 0.05). (J,K) Western blotting displayed that the expression of PCNA was remarkably down-regulated in the CT04 treated cells (n = 6, *P < 0.05). The blots were cropped from different parts of the same gel. The expression level of PCNA in the control group was normalized to 1.