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. 2018 Nov 26;9:4973. doi: 10.1038/s41467-018-07510-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — USP25 is a homotetramer formed by the assembly of two dimers. a Ribbon representation of the USP25 tetramer. Each subunit is represented with a different color. LLC and IL-loop domains are labeled. Different orientations of the USP25 tetramer. b Mixed surface and ribbon representation of the homotetramer structure of USP25. Cartoon image of the tetramer assembly formed by the assembly of two homodimers (A, A′ homodimer and B, B′ homodimer)