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. 2018 Nov 26;8:17359. doi: 10.1038/s41598-018-35012-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SufR_TB protein is essential for Mtb to survive under stress conditions. (A and B) Survival of wild-type, mutant, and complemented strains in 7H9 enriched medium under oxidative (5 mM H₂O₂ for 6 hours) and nitrosative stress (200 μM DETA-NO for 48 hours), respectively. (C) Growth of the ∆ sufR_TB strain relative to the wild-type strain in mouse bone marrow-derived macrophages. Macrophages were infected at an MOI of 1, and a relative growth difference was estimated by counting colony-forming units at day 0 and day 7 after plating. (D) Biofilm formation was observed in wild-type and mutant strains in Sauton’s medium over a period of 4 weeks. Significant differences observed in the groups are marked (unpaired two-tailed t test, *P < 0.005). (E) Estimation of intracellular Fe accumulated in H37Rv, ∆ sufR_TB, and ∆ sufR_TB:pJEB sufR_TB strains.