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. 2018 Nov 26;8:17359. doi: 10.1038/s41598-018-35012-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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∆sufRTB gene is critical for survival of Mtb in the host. (A and B) Bacterial load in mice infected with different Mtb strains through the aerosol route (H37Rv, ∆sufR_TB, and ∆sufR_TB:pJEB sufR_TB) in the lung and spleen, respectively, at week 2, 4, and 8 post infection. The data represents the average colony-forming count from 5 animals in each group. (C and D) The graph depicts the difference in the growth rate of different strains of Mtb in mice at early (2–4 weeks) and late (4–8 weeks) stages of Mtb infection. (E) Gross pathology of the lungs and spleens of animals infected with various strains of Mtb at 8 weeks post infection. Significant differences observed in the groups are marked (unpaired two-tailed t test, *P < 0.005)