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. 2018 Nov 26;8:17369. doi: 10.1038/s41598-018-35030-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemical staining depicting the effects of bvPLA2 treatment on Aβ burdens in the brains of 3xTg-AD mice. Aβ burdens were determined by immunohistochemical staining with anti-Aβ antibodies. (a) Representative images of Aβ staining in the hippocampal CA1 (top) and cortex (bottom) regions. Scale bars 20 µm. Bar graphs of data pertaining to the effects of bvPLA2 treatment on Aβ deposition in (b) hippocampal CA1 and (c) cortex regions. The data are shown as the mean ± SEM. ***P < 0.001 vs. WT; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. 3xTg.