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. 2018 Nov 26;8:17369. doi: 10.1038/s41598-018-35030-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of bvPLA2 on glucose uptake in the brains of 3xTg-AD mice. Voxel-based morphometry revealed right-dominant asymmetry of cerebral glucose metabolism. The result of voxel-based statistical analysis was visualized [¹⁸F]-FDG scans comparing the WT and 3xTg groups, 3xTg and 3xTg/Aβ groups, and 3xTg/Aβ and 3xTg/Aβ + PLA2 groups. Red indicates a region of relatively high glucose metabolism in comparison to corresponding regions. Blue indicates a region of relatively low glucose metabolism in comparison to corresponding regions.