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. 2018 Nov 26;8:17385. doi: 10.1038/s41598-018-35724-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Induction of neutralizing antibodies by MVA-ZIKV in immunocompetent mice. Balb/c mice were immunized with MVA-ZIKV/MVA-ZIKV or MVA-WT/MVA-WT and 10 days after the last immunization ZIKV-specific humoral immune responses were analyzed (see Methods). (a) Percentage of ZIKV plaque reduction. Data represent the percentage of ZIKV plaque reduction, determined by a PRNT assay, from each individual serum sample at different serial dilutions. (b) ZIKV-neutralizing antibody titers. Data represent the reciprocal of the serum dilution that inhibited plaque formation by 90% (PRNT₉₀), relative to samples incubated with negative control sera. Dashed line indicates the limit of detection (LOD) of the neutralization assay (1/20 dilution). The statistically significant difference between both groups is indicated (*P < 0.05).