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. 2018 Nov 26;8:17377. doi: 10.1038/s41598-018-35730-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Excess iron impairs the inhibitory effect of VC against NF-κB activation of K562 cells in vitro. (A) Western blot analysis of NF-κB. *P < 0.01, **P < 0.0001. The values represent the mean ± SD values of triplicate samples. (B) Quantitative real-time polymerase chain reaction analysis of HIF-1α mRNA. *P < 0.0001. The values represent the mean ± SD values of triplicate samples. (C) Western blot analyses of Mcl-1, Bcl-xL, and Bcl-2. *P < 0.01, **P < 0.001. The values represent the mean ± SD values of triplicate samples. (D) Western blot analysis of phosphorylated IκB. *P < 0.001, **P < 0.0001. The values represent the mean ± SD values of triplicate samples. (E) Intracellular VC content. *P < 0.05, **P < 0.001. The values represent the mean ± SD values of triplicate samples.