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. 2018 Nov 26;8:17348. doi: 10.1038/s41598-018-35587-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Methylation dynamics across development and maturation transitions. (a) Bar plot showing the number of hyper- and hypo-differentially methylated regions (DMRs) identified in DevTrans and MatTrans. (b) Heatmap representation of enriched transcription factor binding site (TFBS) motifs in DMRs for each transition. (c, d) In silico transcriptional regulatory networks based on DMR target gene interactions during DevTrans (green connecting line) and MatTrans (red connecting line). Known deafness transcription factors (TFs)/genes are marked by purple squares. TF-target gene interactions are clustered according to common GO terms (indicated by various color and patterned filled areas). Centralized specific TF in silico transcriptional regulatory networks around the hair cell marker, Stat3 (c) or supporting cell marker Sox2 (d). All direct interactions with centralized TFs are indicated by bold lines. (e) The enriched GO biological process terms and pathways for the overall regulatory networks of DevTrans (top) and MatTrans (bottom) (Table S7), number of GO term connected genes are shown in white.