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. 2018 Nov 26;8:17348. doi: 10.1038/s41598-018-35587-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of time point-specific unmethylated region (UMR) and low-methylated region (LMR) putative regulatory regions. (a) Time point-specific UMRs (5,692) and LMRs (314,192) and their dynamics through the time points, represented as Sankey plots; regions defined at a specific time point as UMR/LMR (dark grey) and regions not defined as UMR/LMR (light grey). (b) GO term enrichment analysis of time point-specific UMR (top) and time point-specific LMR (bottom) associated genes; for UMR analysis, Circle fill is according to P value (<0.05) and for time point-specific LMR according to q value (FDR < 0.05). Circle diameter is proportional to the number of genes associated with each term.