Table 2.

Numbers of DEGs identified in brain regions and their overlapping in blood.

Region	Brain AD DEGs			Blood AD DEGs				Blood MCI DEGs				Region names
	Up	Down	All	Up	Down	All	Ratio	Up	Down	All	Ratio
PFC	526	94	620	182	29	211	0.34	240	38	278	0.45	Prefrontal Cortex
OVC	154	73	227	62	15	77	0.34	77	16	93	0.41	Occipital Visual Cortex
DPC	238	87	325	79	17	96	0.30	109	26	135	0.42	Dorsolateral Prefrontal Cortex
STG	297	1607	1904	65	494	559	0.29	90	749	839	0.44	Superior Temporal Gyrus
AC	391	125	516	109	39	148	0.29	161	57	218	0.42	Anterior Cingulate
ITG	839	104	943	259	9	268	0.28	359	15	374	0.4	Inferior Temporal Gyrus
SPL	29	313	342	9	85	94	0.27	14	136	150	0.44	Superior Parietal Lobule
PU	46	201	247	8	58	66	0.27	12	77	89	0.36	Putamen
PCC	16	63	79	1	20	21	0.27	7	25	32	0.41	Posterior Cingulate Cortex
NA	864	527	1391	221	109	330	0.24	300	137	437	0.31	Nucleus Accumbens
IFG	94	241	335	15	62	77	0.23	22	88	110	0.33	Inferior Frontal Gyrus
CN	52	155	207	5	39	44	0.21	7	58	65	0.31	Caudate Nucleus
PG	5	9	14	1	2	3	0.21	1	1	2	0.14	Precentral Gyrus
AG	559	251	810	101	58	159	0.20	155	82	237	0.29	Amygdala
PHG	254	117	371	54	21	75	0.20	75	28	103	0.28	Parahippocampal Gyrus
TP	50	8	58	7	3	10	0.17	7	3	10	0.17	Temporal Pole
MTG	21	10	31	3	2	5	0.16	6	4	10	0.32	Middle Temporal Gyrus
FP	98	34	132	13	7	20	0.15	18	12	30	0.23	Frontal Pole
HIP	40	32	72	2	9	11	0.15	7	13	20	0.28	Hippocampus

This table shows the number of DEGs identified in 19 brain regions, and their overlap with DEGs in the blood. The Ratio column in the table indicates the proportion of brain DEGs which are also DEGs in blood. For example, there are 620 DEGs identified in the brain Prefrontal Cortex (PFC) region, 211 of them (Ratio = 0.34) are also DEGs in AD blood, and 278 of them (Ratio = 0.45) are DEGs in MCI blood. The PFC region has the highest proportion of DEGs which are also DEGs in the blood, both for AD and MCI patients.