Table 1.
Memory CD8 T cell subsets.
| Subset | Phenotype | Function | Location/Trafficking | Transcription factors | References |
|---|---|---|---|---|---|
| Tem | CCR7lo/CD62Llo Cx3Cr1hi/CD27lo CD127hi CD27−/CD45RA− (humans) | ++ Cytotoxicity +- Proliferation | Circulation | Tbethi Blimp1hi/ID2hi/STAT4hi | (30, 37–44) |
| Tcm | CCR7hi/CD62Lhi Cx3Cr1lo/CD27hi CD127hi CD27+/CD45RA− (humans) | +− Cytotoxicity ++ Proliferation | Circulation Lymph nodes | Tbetlo Eomeshi/TCF1hi/Bcl6hi/ STAT3hi/ID3hi | (30, 37–39, 42–49) |
| Temra (humans) | CCR7−/CD27−/CD45RA+ CD127lo | ++ Cytotoxicity +− Proliferation | Circulation | (44) | |
| Trm | CD69hi/CD103hi/CD49ahi (depending on tissue) CXCR3hi/KLRG1lo/CCR7lo/ CD62Llo, CD127hi Cx3Cr1lo/int | Sensing and alarm + proliferation | Tissue resident | KLF2−/lo/Eomes−/lo Tbetlo/TCF1lo Hobithi/Blimp1hi | (33, 43, 50–60) |
| Tpm | CCR7+/−/CD62L+/−/CD127hi Cx3Cr1int/CD27hi | + Cytotoxicity + Proliferation | Circulation Tissue trafficking Lymph nodes | Tbet+/− | (43, 61, 62) |
| Others | CD27lo/CD43lo KLRG1hi, CD127lo | ++ Cytotoxicity +− Proliferation | Tissue trafficking | Tbethi/Eomeslo | (32, 62) |