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Remote signalling by the microbiota stimulates VWF synthesis in the hepatic endothelium of mice, promoting thrombus growth in the ligation‐injured carotid artery. (1) Microbial products from the gut lumen translocate from the gut lumen to the liver, where they (2) stimulate TLR2, leading to increased hepatic VWF synthesis and release into the circulation. (3) Elevated VWF plasma levels promote platelet deposition and thrombus growth in the injured carotid artery.
