Figure 1.

Treatment with DDC improves hepatic steatosis in rats fed a MCD diet for 6 weeks. Male SD rats were fed either MCD or MCS diets for 6 weeks. The MCD group were treated either with vehicle (1 × PBS) or 312 mg·kg⁻¹ DDC via daily gavage for all 6 weeks. (A) H&E and Oil red O staining of representative liver sections (original magnification ×200) shows the distribution of lipid. (B) Scores of liver steatosis and the area of the Oil red O in liver sections were measured. (C) Serum CHO (mmol^.L^‐1) and HDL (mmol^.L^‐1) levels in rats. (D) The transcript levels of genes related to fatty acid synthesis (Fas and Scd1). Data are expressed as mean ± SEM; n = 10 rats per group. One‐way ANOVA followed by Dunnett's post hoc test for multiple comparisons. *P < 0.05.