Table 1.

Study characteristics of included studies (cohort studies).

Study	Country	Year	N	Study design	Statistical method	Pathogen numbers	Follow-up years	Outcome	Significant prognostic factors from multivariate analysis or from univariate analysis with p < 0.05	NOS scale
Daoud et al. 9	Jordan	1992–1994	53	Prospective	Multivariate	12	8–30 m (mean 16.4 m)	Mortality and Sequela	Bulging anterior fontanelle, altered sensorium	8
Chang et al. 13	China, Taiwan	1986–2001	60	Retrospective	Multivariate	14	6 m after treatment	Mortality and Sequela	Seizure, fontanelle bulging, thrombocytopenia, CSF total protein, CSF glucose	7
Lin et al. 11	China, Taiwan	1984–2008	156 (7 lost)	Retrospective	Multivariate	19	1–2 year	Mortality and Sequela	Early onset, preterm, CSF pro > 500 mg/dl at admission, predisposing to congenital heart disease, hearing impairment, seizure	7
Klinger et al. 22	Canada	1979–1998	101	Retrospective	Multivariate	9	At 1 year of age	Mortality and Sequela	Seizure, coma, need for ventilation support, leukopenia	7
Tan et al. 12	China	2008–2014	232	Retrospective	Multivariate	11	Discharge day or at an age of 2.5–3 m	Mortality and Sequela	CSF protein, pneumonia, poor feeding, PLT	6
Kamoun et al. 14	Tunisa	1990–2012	55 (9 lost)	Retrospective	Univariate	12	1–11 year	Mortality and Sequela	Altered consciousness, CSF protein, CSF glucose	6
Bell et al. 19	Northern Ireland	1973–1986	41	Retrospective	Univariate	8	At 2 years of age or older by pediatrician	Mortality	Weight < 2,500 g, positive CSF culture	6