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. 2018 Nov 20;9:2707. doi: 10.3389/fimmu.2018.02707

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Copyright © 2018 Raam, Kaleviste, Šunina, Vaher, Saare, Prans, Pihlap, Abram, Karelson, Peterson, Rebane, Kisand and Kingo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WIPI1 expression and LC3 staining. (A) WIPI1 relative mRNA expression in the skin of control subjects (CS), and in the perilesional skin (VLS) and non-lesional skin (VNLS) of vitiligo patients. Geometric mean ×÷ geometric standard deviation is indicated. **p < 0.01; and ***p < 0.001. (B) WIPI1 relative mRNA expression in various cell types of the skin. Geometric mean ×÷ geometric standard deviation is indicated. 2D, two-dimensional; ALI, air-liquid interface; moLC, monocyte derived Langerhans cells. (C) Immunofluorescence image of LC3 (microtubule-associated protein 1A/1B-light chain 3) and TYRP1(tyrosinase related protein 1) in sections of biopsy samples from control subjects (CS), and lesional skin (VLS) and non-lesional skin (VNLS) of vitiligo patients. The white bar represents 5 μm. (D) Immunofluorescence image as in panel C with the white bar representing 20 μm. Neg. refers to a control slide with secondary antibodies only. (E) The box and whiskers plots show the median and interquartile range of the ratio between the fluorescence signal marking LC3 expression and DAPI (cell nuclei) in CS, VNLS, and VLS. Whiskers cover data points within a 1.5× interquartile range. *p < 0.05.