Table 2.
Expression of IL-33 receptor ST2 in central nervous system cells.
| Tissue or cells | Neuron (NeuN Ab or stated) | Astrocyte (GFAP Ab or stated) | Microglia (Ab tested) | Oligodendrocytes (Olig 2 Ab or stated) | References |
|---|---|---|---|---|---|
| Mouse mixed glia culture: St2 and IL-1RAcP mRNA | √ (IL-1RAcP only) | √ | √ | NT | (14) |
| Mouse mixed glia culture: St2 mRNA | NT | √ | √ | NT | (12) |
| Rat myelinating co-culture | √ | ND | NT | √ (O4) | (13) |
| MS patient brain | √ (SMI-31) | NT | NT | √ (CA-II) | (13) |
| Mouse brain | ND (by FC) | √ (GLAST) (by FC) | √ (Iba-1) | ND (by FC) | (28) |
| Mouse thalamus and spinal cord flow sorted cells (St2 mRNA) | ND | ND | √ | NT | (16) |
| Mouse spinal cord | √ | ND | NT | NT | (29) |
| Mouse spinal cord | √ | √ | ND (CD11b) | NT | (36) |
| Mouse dorsal root ganglia | √ (Nissi) | NT | NT | NT | (36) |
| Human DRG: St2 and IL-1RAcP mRNA | √ | NT | NT | NT | (36) |
| Mouse spinal cord (EAE) | NT | √ | NT | √ (O1) | (37) |
| Rat spinal cord | √ | √ | ND (OX-42) | √ | (35) |
Expression of St2 mRNA was performed using PCR while protein expression was studied using immunohistochemical staining or other methods. √, positive expression of ST2; ND, not detectable; NT in gray square, not tested. Ab, antibody; EAE, experimental autoimmune encephalomyelitis; FC, flow cytometry; MS, multiple sclerosis; DRG, dorsal root ganglia.