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. 2018 Nov 20;9:1339. doi: 10.3389/fphar.2018.01339

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Copyright © 2018 Gisselmann, Alisch, Welbers-Joop and Hatt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACh concentration–response relationship at human adult muscle nAChRs in the presence and absence of 1.8 μM quinine measured in Xenopus oocytes. Currents were elicited by various ACh concentrations. (A) Concentration-response curves for human adult muscle nAChRs in the presence (open circles) and the absence (filled circles) of 1.8 μM quinine (n = 6). (B) Relative current blocked by 1.8 μM quinine at 10, 30, and 100 μM ACh. Holding potential: -60 mV, error bars represent S.E.M.