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Visual predictive checks (VPCs) on dose‐normalized concentrations for (A) single ascending doses (B) and 4‐day and (C) 7‐day multiple ascending doses. The red lines represent the 5th, 50th, and 95th percentiles of the observed data (orange circles), the shaded grey areas are the 95% confidence intervals of the 5th and 95th percentiles of the simulated data, and the pink shaded areas are the 90% confidence intervals of the 50th percentiles of the simulated data
