Table 4.
Population PK parameter estimates
| Parameter | Estimate | SE | RSE | |
|---|---|---|---|---|
|
Fixed
effect |
KA (h−1) | 2.400 | 0.356 | 14.80% |
| CL (l h−1) | 52.400 | 2.420 | 4.60% | |
| VC (l) | 1150.000 | 70.200 | 6.10% | |
| Q (l h−1) | 24.900 | 3.130 | 12.60% | |
| V3(l) | 539.000 | 20.800 | 3.90% | |
| LAG (h) | 0.244 | 0.0016 | 0.70% | |
| DayV | 0.079 | 0.0129 | 16.40% | |
| DoseV | 0.002 | 0.0004 | 14.60% | |
| DayCL | 0.056 | 0.0065 | 11.60% | |
| DoseCL | 0.002 | 0.0002 | 14.90% | |
| Add error | 1.270 | 0.418 | 32.90% | |
| Prop error | 0.200 | 0.0084 | 4.20% | |
|
Random
effect a |
KA | 1.220 | 0.328 | 26.90% |
| CL | 0.077 | 0.013 | 16.60% | |
| VC | 0.093 | 0.017 | 18.00% | |
| V3 | 0.025 | 0.010 | 38.20% | |
| LAG | 0.0004 | 0.0002 | 63.50% |
SE, standard error; RSE, relative standard error
a
The random effect values represent the IIV variance