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Estimated net endothelin‐antagonistic activity of macitentan and aprocitentan [net activity = AUCmacitentan + (AUCaprocitentan/5)] at macitentan steady‐state, in the presence and absence of single rivaroxaban doses and during induction with St. John's Wort in 12 healthy volunteers. Dashed line = mean curve, *P < 0.01
