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. 2018 Nov 20;8:518. doi: 10.3389/fonc.2018.00518

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Copyright © 2018 Mollen, Ient, Tjan-Heijnen, Boersma, Miele, Smidt and Vooijs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Notch receptor maturation and pathway activation, targetable options, and receptor functionality. (A) Stepwise representation of the process of Notch receptor maturation until receptor activation, followed by transcriptional output (not shown), and possibilities in targeting the Notch receptor pathway. (B) Notch receptor functional domains and corresponding functions ANK, Ankyrin repeats; LNR, Lin12-Notch Repeats and RAM, RBP-jk association module.