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. 2018 Nov 20;9:2804. doi: 10.3389/fmicb.2018.02804

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Copyright © 2018 Moshiri, Kaur, Hambira, Sandala, Koopman, Fuchs and Gunn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T315 inhibits early stages of S. Typhimurium biofilm formation. (A) Chemical structure of T315. (B) S. Typhimurium viability over 24 h is unchanged in the presence of 10 μM T315 (white squares) as compared to the DMSO control (black circles). Multiple t-tests with the Holm-Sidak correction for multiple comparisons revealed no significant differences at any timepoint. (C) In delayed drug administration assays, delivery of 5 μM T315 to developing biofilms was delayed 1, 3, and 6 h post-initial incubation. Average anti-biofilm activity of T315 against S. Typhimurium biofilms was calculated by comparisons of biofilm levels to a DMSO control. ^∗∗∗p < 0.001, ^∗∗p < 0.01, ^∗p < 0.05; repeated measures one-way ANOVA.