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. 2018 Nov 20;9:1312. doi: 10.3389/fphar.2018.01312

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Copyright © 2018 Zhao, Huang, Shi, Dai, Wu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxic effects of gefitinib in acquired gefitinib-resistant NSCLC cell lines and their parental cells. PC9, PC9/GR (A) and H292, H292/GR (B) cells were cultured in 96-well plates and exposed to the indicated concentrations of gefitinib for 72 h. The cell viability was analyzed using MTS assay as described in Meterials and Methods. The number of viable cells is expressed as a percentage of the value for untreated cells. *P < 0.05, **P < 0.01 compared to the parent-sensitive cell line.