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. 2018 Nov 20;9:1312. doi: 10.3389/fphar.2018.01312

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Copyright © 2018 Zhao, Huang, Shi, Dai, Wu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ABCC10 on gefitinib sensitivity in PC9 xenograft mice model. Nude mice were implanted subcutaneously with the indicated cell lines and were treated with gefitinib (30 mg/kg/day) for 3 weeks (n = 6 per group). (A) Average body weight curves of Balb/c-nude mice. (B) TV was measured as indicated in Materials and methods. (C) Tumor weights were analyzed at the end of experiment. (D) Proliferation was detected using anti-Ki-67 antibody. Graphs show the percentage of Ki-67-positive cells in each group. Photos of IHC staining are representative of at least 10 similar observations (× 400). *P < 0.05 compared to the PC9/GR-shMock or PC9-EV group.