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. 2018 Nov 20;9:1312. doi: 10.3389/fphar.2018.01312

Figure 9.

Figure 9

Intracellular gefitinib concentration in LLC-PK1 cells either wildtype (LLC-WT) or transduced with human ABCC10 (LLC-ABCC10) or ABCG2 (LLC-ABCG2) cDNA. cells were incubated with 1, 10, 20, and 50 μmol/L gefitinib at 37°C for 4 h, then the intracellular gefitinib concentration was determined by LC-MS/MS assay and expressed as nmol/mg of protein. *P < 0.05, **P < 0.01 compared to the LLC-WT cells.