Figure 9.
Intracellular gefitinib concentration in LLC-PK1 cells either wildtype (LLC-WT) or transduced with human ABCC10 (LLC-ABCC10) or ABCG2 (LLC-ABCG2) cDNA. cells were incubated with 1, 10, 20, and 50 μmol/L gefitinib at 37°C for 4 h, then the intracellular gefitinib concentration was determined by LC-MS/MS assay and expressed as nmol/mg of protein. *P < 0.05, **P < 0.01 compared to the LLC-WT cells.