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. 2018 Nov 20;9:1202. doi: 10.3389/fphar.2018.01202

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Copyright © 2018 Oyagawa, de la Harpe, Saroz, Glass, Vernall and Grimsey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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cAMP signalling in HEK Flp-in hCB₂ and HEK Flp-in wt cells in response to CP 55,940 and 2,4,6-trisubstituted 1,3,5-triazines. Concentration-response curves for modulation of cAMP concentration in HEK Flp-in hCB₂ and HEK Flp-in wt cells (showing both hCB₂- and non-hCB₂-mediated effects) on stimulation with 5 μM forskolin and CP 55,940 or test compounds (other than 13). Concentration-response curves were generated by plotting measurements at 5 min post-drug addition. These data were then normalised to vehicle-treated (V; 0%) and forskolin alone (F, Fsk; 100%). Data are presented as mean ± SEM from three independent experiments.