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. 2018 Nov 20;9:1202. doi: 10.3389/fphar.2018.01202

Table 3.

Signalling pathway transduction ratios (logR) and transducer function slopes (“n”), with between-pathway delta–delta transduction ratios (ΔΔlogR) and bias factors relative to reference ligand CP 55,940.

logR [log(τ /KA)] (±SEM)
cAMP – pERK
cAMP – internalisation
Internalisation – pERK
Compound # Internalisation cAMP pERK ΔΔlogR (±SEM) Bias factor ΔΔlogR (±SEM) Bias factor ΔΔlogR (±SEM) Bias factor
CP 55,940    8.76 (0.1) 8.52 (0.02) 8.05 (0.03)    0.00 (0.04) 1.0      0.01 (0.10) 1.0    –0.02 (0.11) 1.0
7    7.42 (0.26) 7.29 (0.26) 5.51 (0.05)    1.31 (0.27)*** 20.3      0.12 (0.31) 1.3      1.19 (0.16)*** 15.4
10    7.09 (0.10) 6.90 (0.10) 6.06 (0.02)    0.37 (0.10) 2.4      0.07 (0.16) 1.2      0.31 (0.13) 2.0
14    6.81 (0.23) 5.83 (0.23) 5.16 (0.09)    0.20 (0.25) 1.6    –0.73 (0.25)* 0.2      0.93 (0.13)** 8.6
15    8.92 (0.09) 8.12 (0.09) 7.45 (0.10)    0.20 (0.13) 1.6    –0.56 (0.15) 0.3      0.76 (0.15)* 5.7
16    8.90 (0.19) 8.52 (0.19) 7.84 (0.07)    0.21 (0.20) 1.6    –0.14 (0.22) 0.7      0.35 (0.13) 2.2
nΔ    1.49 (0.21) 1.28 (0.14) 1.14 (0.06)

The symbol “” indicates significant difference from CP 55,940 for the same bias comparison; significance levels as defined in the methods. Δn” is the transducer function slope which was determined for each signalling pathway as a shared constraint between ligands when fitting the operational model.