Figure 1.

Immunohistochemical expressions of SIRT6 and active β-catenin, and statistical analysis in ovarian carcinomas. (A) Immunohistochemical expressions of SIRT6 and active β-catenin are seen in both the cytoplasm and nuclei of tumor cells. (B) Receiver operator characteristic curve analysis to determine the cut-off points for the immunohistochemical staining for SIRT6 and active β-catenin. The cut-off points were determined at the highest area under the curve (AUC) value. The cut-off points for nuclear expression of SIRT6 (arrow), cytoplasmic expression of SIRT6 (arrow head), nuclear expression of active β-catenin (empty head), and cytoplasmic expression of active β-catenin (empty arrow head) were seven, seven, five, and five, respectively. The table shows AUC and P values at cut-off points for the nuclear and cytoplasmic expressions of SIRT6 and active β-catenin.