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. 2018 Nov 20;9:965. doi: 10.3389/fneur.2018.00965

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Copyright © 2018 Li, Li, Chopp, Venkat, Zacharek, Chen, Landschoot-Ward, Yan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICH significantly increases systemic inflammatory factor expression and oxidative stress compared to sham control mice. (A) Western blot assay shows that ICH significantly increases systemic inflammatory factor expression at 7 days after ICH such as (B) intercellular adhesion molecule-1 (ICAM-1), (C) Molecular interleukin-1beta (IL-1β) and (E) Transforming growth factor beta (TGF-β). ICH also significantly increases oxidative stress indicated by (D) NADPH oxidase-2 (NOX-2) expression in serum. Data are presented as mean ± SE, ^*p < 0.05 compared with sham control.